The melody of What Can You Lose by Madonna runs 140 notes across 32 bars, 1:42 long in B at 108 beats per minute. The tab sits low on the neck, mostly under the fourth fret, one note at a time — no chords to barre and no strumming pattern to keep up with. A piano backing track plays the chords and bass underneath, so the line you are learning sounds like the record even at half speed.
Prefer to strum and sing it instead? What Can You Lose chords and lyrics.