The melody of U.s. Blues by Grateful Dead runs 192 notes across 41 bars, 3:52 long in A at 120 beats per minute. The tab sits low on the neck, mostly under the fourth fret, one note at a time — no chords to barre and no strumming pattern to keep up with. A piano backing track plays the chords and bass underneath, so the line you are learning sounds like the record even at half speed.
Prefer to strum and sing it instead? U.s. Blues chords and lyrics.