The melody of On The Road Again by Willie Nelson runs 167 notes across 45 bars, 1:24 long in E at 200 beats per minute. The tab sits almost entirely in the first two frets, one note at a time — no chords to barre and no strumming pattern to keep up with. A piano backing track plays the chords and bass underneath, so the line you are learning sounds like the record even at half speed.
Prefer to strum and sing it instead? On The Road Again chords and lyrics.