The melody of Iko Iko by Dr. John runs 441 notes across 33 bars, 3:45 long in D at 80 beats per minute. The tab sits almost entirely in the first two frets, one note at a time — no chords to barre and no strumming pattern to keep up with. A piano backing track plays the chords and bass underneath, so the line you are learning sounds like the record even at half speed.
Prefer to strum and sing it instead? Iko Iko chords and lyrics.