The melody of Handle With Care by The Traveling Wilburys runs 110 notes across 23 bars, 1:17 long in G at 112 beats per minute. The tab sits low on the neck, mostly under the fourth fret, one note at a time — no chords to barre and no strumming pattern to keep up with. A piano backing track plays the chords and bass underneath, so the line you are learning sounds like the record even at half speed.
Prefer to strum and sing it instead? Handle With Care chords and lyrics.